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Curr Biol. 2005 Sep 6;15(17):R665-8.

Transcriptional regulation: cancer, neurons and the REST.

Author information

  • 1Physiological Laboratory and Department of Human Anatomt & Cell Biology, School of Biomedical Sciences, University of Liverpool, Crown St, Liverpol L69 3BX, UK. j.m.coulson@liv.ac.uk

Abstract

REST/NRSF was first identified as a transcriptional repressor of neuronal genes in non-neuronal cells. Recent studies have now revealed seemingly paradoxical roles for REST/NRSF in neurogenesis, neural plasticity, tumour suppression and cancer progression.

PMID:
16139198
DOI:
10.1016/j.cub.2005.08.032
[PubMed - indexed for MEDLINE]
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