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Eur Neuropsychopharmacol. 2005 Oct;15(5):521-4.

SERT and DAT availabilities under citalopram treatment in obsessive-compulsive disorder (OCD).

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1
Department of Psychiatry, Section of Clinical Neurophysiology, Ludwig-Maximilians-University of Munich, Nussbaumstr. 7, D-80336 Munich, Germany. oliver.pogarell@med.uni-muenchen.de

Abstract

Serotonin and dopamine transporter (SERT, DAT) availabilities have prospectively been investigated using [123I]beta-CIT and single photon emission computed tomography in subjects with obsessive-compulsive disorder under treatment with the selective serotonin reuptake inhibitor citalopram. SERT availability decreased by a mean 36.5%, whereas DAT availability increased by about 40%. The data point at a citalopram induced modulation of both serotonergic and dopaminergic activity and support the notion of functional interactions of monoaminergic systems in the human brain.

PMID:
16139170
DOI:
10.1016/j.euroneuro.2005.01.003
[Indexed for MEDLINE]
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