Format

Send to

Choose Destination
Synapse. 2005 Dec 1;58(3):193-9.

Effects of sarizotan on the corticostriatal glutamate pathways.

Author information

1
Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Ferrara, Italy.

Abstract

The effects of sarizotan, a 5-HT(1A) agonist with additional affinity for D(3) and D(4) receptors, have been studied on the corticostriatal glutamate pathways using dual-probe microdialysis in the awake rat. Sarizotan given systemically (0.1-10 mg/kg s.c.) or perfused into the motor cortex (10 microM) produced 20-30% reduction of cortical and striatal glutamate levels. The inhibitory effects of the systemic sarizotan on cortical and striatal glutamate levels were counteracted by intracortical perfusion with the 5-HT(1A) antagonist WAY100135 (10 microM). These findings suggest that the anti-dyskinetic properties of sarizotan could be mediated via its 5-HT(1A) agonist actions in the motor cortex, leading to reduced activity in the corticostriatal glutamate pathways with reduced activation of the striatopallidal GABA pathway mediating motor inhibition.

PMID:
16138317
DOI:
10.1002/syn.20195
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center