Format

Send to

Choose Destination
See comment in PubMed Commons below
Histol Histopathol. 2005 Oct;20(4):1267-74. doi: 10.14670/HH-20.1267.

Cox and mesothelioma: an overview.

Author information

1
SAFU Department, Center for Experimental Research, Regina Elena Cancer Institute, Rome, Italy.

Abstract

Cyclooxygenases catalyze the rate limiting step in the production of prostanoids. Accumulating data demonstrate that overexpression of these enzymes, and in particular of cyclooxygenases-2, promotes multiple events involved in tumorigenesis; in addition, numerous studies show that inhibition of cyclooxygenases-2 can delay or prevent certain forms of cancer. Malignant mesothelioma is a lethal pleural, peritoneal and pericardial neoplasia that actually lacks valid therapies and in which cyclooxygenases-2 is recognized as an important adverse prognostic factor. Hence, there is an increasing interest in the development of new treatments based on cyclooxygenases-2 inhibitors, to prolong survival and even potentially cure this neoplasia.

PMID:
16136507
DOI:
10.14670/HH-20.1267
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Sercrisma International S.L.
    Loading ...
    Support Center