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Nat Rev Neurosci. 2005 Sep;6(9):671-82.

The origin and development of glial cells in peripheral nerves.

Author information

1
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. k.jessen@ucl.ac.uk

Abstract

During the development of peripheral nerves, neural crest cells generate myelinating and non-myelinating glial cells in a process that parallels gliogenesis from the germinal layers of the CNS. Unlike central gliogenesis, neural crest development involves a protracted embryonic phase devoted to the generation of, first, the Schwann cell precursor and then the immature Schwann cell, a cell whose fate as a myelinating or non-myelinating cell has yet to be determined. Embryonic nerves therefore offer a particular opportunity to analyse the early steps of gliogenesis from transient multipotent stem cells, and to understand how this process is integrated with organogenesis of peripheral nerves.

PMID:
16136171
DOI:
10.1038/nrn1746
[Indexed for MEDLINE]

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