Format

Send to

Choose Destination
Nature. 2005 Sep 1;437(7055):45-6.

Phytochemistry: ibuprofen-like activity in extra-virgin olive oil.

Author information

1
Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA.

Abstract

Newly pressed extra-virgin olive oil contains oleocanthal--a compound whose pungency induces a strong stinging sensation in the throat, not unlike that caused by solutions of the non-steroidal anti-inflammatory drug ibuprofen. We show here that this similar perception seems to be an indicator of a shared pharmacological activity, with oleocanthal acting as a natural anti-inflammatory compound that has a potency and profile strikingly similar to that of ibuprofen. Although structurally dissimilar, both these molecules inhibit the same cyclooxygenase enzymes in the prostaglandin-biosynthesis pathway.

PMID:
16136122
DOI:
10.1038/437045a
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center