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Am J Psychiatry. 2005 Sep;162(9):1738-40.

Relation of plasma glycine, serine, and homocysteine levels to schizophrenia symptoms and medication type.

Author information

  • 1Ezrath Nashim-Herzog Memorial Hospital, P.O. Box 3900, Jerusalem 91035, Israel.

Abstract

OBJECTIVE:

Altered glycine and homocysteine levels may contribute to N-methyl-D-aspartate receptor dysfunction in schizophrenia. The authors measured plasma levels of these amino acids in a group of patients with chronic schizophrenia and related them to the patients' symptom profiles and types of antipsychotic medication.

METHOD:

Plasma levels of amino acids in 94 patients with schizophrenia were compared with those in 34 age- and sex-matched normal subjects. The Positive and Negative Syndrome Scale was used to evaluate the patients' psychopathology.

RESULTS:

Plasma glycine levels and glycine-serine ratios were lower and homocysteine levels were higher in patients than in comparison subjects. Low glycine levels correlated with a greater number of negative symptoms. The glycine-serine ratios of normal subjects and patients being treated with clozapine did not differ significantly.

CONCLUSIONS:

These findings support the hypothesis that altered levels of glycine and homocysteine may coexist in patients with schizophrenia and contribute to pathophysiological aspects of this illness.

PMID:
16135636
DOI:
10.1176/appi.ajp.162.9.1738
[PubMed - indexed for MEDLINE]
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