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Eur J Clin Nutr. 2006 Jan;60(1):62-8.

A randomized controlled trial of dietary fiber intake on serum lipids.

Author information

1
Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA.

Abstract

OBJECTIVE:

Clinical trials have indicated that water-soluble fiber from oats reduces serum cholesterol among hypercholesterolemic patients on a low-fat diet. We examined the effect of dietary fiber intake on serum lipids among persons without hypercholesterolemia.

DESIGN:

Randomized controlled trial.

SETTING AND SUBJECTS:

We recruited 110 participants who were aged 30-65 years and had a serum cholesterol level < 240 mg/dl from community.

INTERVENTION:

Study participants were randomly assigned to receive 8 g per day of water-soluble fiber from oat bran or a control intervention.

RESULTS:

At baseline, the mean levels of serum cholesterol and other measured variables were comparable between the high-fiber and control groups. Over the 3-month intervention, mean changes (95% confidence interval (CI)) in total, HDL-, and LDL-cholesterol were -2.42 mg/dl (-8.90 to 4.05 mg/dl; P = 0.46), -0.24 mg/dl (-2.19 to 1.71 mg/dl; P = 0.81), and -1.96 mg/dl (-7.32 to 3.40 mg/dl; P = 0.47) in the fiber group and -0.02 mg/dl (-5.29 to 5.26 mg/dl; P = 0.99), 1.42 mg/dl (-0.74 to 3.59 mg/dl; P = 0.19), and -0.64 mg/dl (-5.30 to 4.03 mg/dl; P = 0.79) in the control group, respectively. The net changes (95% confidence interval) in total, HDL-, and LDL-cholesterol were -2.40 mg/dl (-10.6 to 5.81 mg/dl; P = 0.56), -1.66 mg/dl (-4.55 to 1.22 mg/dl; P = 0.26) and -1.33 mg/dl (-8.33 to 5.68 mg/dl; P = 0.71), respectively.

CONCLUSIONS:

Our study does not support the hypothesis that water-soluble fiber intake from oat bran reduces total and LDL-cholesterol in study participants with a normal serum cholesterol level.

PMID:
16132055
DOI:
10.1038/sj.ejcn.1602268
[Indexed for MEDLINE]

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