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Biosens Bioelectron. 2006 Feb 15;21(8):1560-5. Epub 2005 Aug 29.

Ultra-high redox enzyme signal transduction using highly ordered carbon nanotube array electrodes.

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Division of Engineering, Brown University, Providence, RI 02912, USA.


We report on a highly ordered array of carbon nanotubes (CNTs) that serves as a universally direct nanoelectrode interface for redox proteins and provides an efficient conduit for electron transfer. The site-selective, covalent docking of the enzyme glucose oxidase (GO(x)) on the CNT tips is found to have a marked effect on enhancing electron transfer properties, as measured by cyclic voltammetry. A unimolecular electron transfer rate of 1500 s(-1) has been measured for this system, a value exceeding the rate of oxygen reduction by glucose oxidase. Furthermore, the redox enzyme-CNT array conjugate can be utilized as a quantitative, substrate-specific biosensor.

[Indexed for MEDLINE]

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