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Ann N Y Acad Sci. 2005 Jun;1051:515-28.

Synergistic effect of Avemar on proinflammatory cytokine production and Ras-mediated cell activation.

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1
Chemotherapy Day-Ward Unit, National Institute of Oncology, Ráth György u. 7-9, 1122 Budapest, Hungary. telekes@oncol.hu

Abstract

Macrophages activated by lipopolysaccharide and/or phorbol esters exhibited high sensitivity to Avemar, a fermented wheat germ extract. Avemar synergized with lipopolysaccharide and PMA in the induction of the transcription of cytokine genes and release of inflammatory cytokines. At higher concentrations the preparation had a significant negative effect on the proliferation and survival of activated myeloid cell types. Avemar treatment induced the synthesis of ICAM-1 and synergized with the ICAM-inducing effect of TNF, but had no effect on VCAM-1 expression on microvascular endothelial cells. The effect of Avemar on signaling pathways, which are involved in cell activation was studied on HeLa cells as a model system. Avemar treatment increased the activity of stress kinases in a concentration-dependent way, resulting in the activation of AP-1 transcription factor. NF-kappa B-sensitive reporters were also activated by Avemar; in contrast, no effect of the preparation was observed on PKA-sensitive signaling pathways.

PMID:
16126992
DOI:
10.1196/annals.1361.096
[Indexed for MEDLINE]
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