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Diabetes Res Clin Pract. 2005 Oct;70(1):38-45. Epub 2005 Apr 18.

Heterogeneity of early-onset and ketosis-resistant diabetes in Korean subjects--is it possible to determine cut-off age of early-onset type 2 diabetes?

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  • 1Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Republic of Korea.

Abstract

OBJECTIVE:

To investigate the heterogeneity of early-onset and ketosis-resistant diabetes and to define a not-arbitrary cut-off age for early-onset diabetes based on its clinical and metabolic characteristics, and diabetes complications.

METHODS:

We classified 1015 early-onset diabetes subjects aged 21-40 into four groups (group I, age at diagnosis 21-25 years; group II, 26-30; group III, 31-35; group IV, 36-40). Familial and diabetic history, statue of insulin secretion, metabolic parameters, and diabetes complications were analyzed.

RESULTS:

No significant difference in family history or the rate of diabetic complication was found in the four groups. Subjects with a 21 to a 25-year-old diabetes onset had the lowest serum C-peptide levels, with 50% of the cumulative 24-h urine C-peptide levels of the other three groups (p<0.0001). This group also had the lowest prevalence of hyperlipidemia and arterial hypertension (p<0.01 and <0.0001, respectively). Group III was found to have a higher prevalence of insulin insufficiency and hypertension than group IV.

CONCLUSION:

Our data based on insulin secretory function and metabolic factors might suggest that a cut-off age of 26 years might be warranted in Korean patients. Korean early-onset type 2 diabetes patients tend to be non-obese and insulin secretory dysfunction.

PMID:
16126122
DOI:
10.1016/j.diabres.2005.02.014
[PubMed - indexed for MEDLINE]
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