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J Pediatr. 2005 Aug;147(2):197-201.

The use of Lactobacillus GG in irritable bowel syndrome in children: a double-blind randomized control trial.

Author information

1
Department of Pediatrics, Wright State University School of Medicine and The Children's Medical Center, Dayton, Ohio 45404, USA.

Erratum in

  • J Pediatr. 2014 Oct;165(4):878. Bausserman, Melissa [corrected to Bauserman, Melissa].

Abstract

OBJECTIVE:

To determine whether oral administration of the probiotic Lactobacillus GG under randomized, double-blinded, placebo-controlled conditions would improve symptoms of irritable bowel syndrome (IBS) in children.

STUDY DESIGN:

Fifty children fulfilling the Rome II criteria for IBS were given Lactobacillus GG or placebo for 6 weeks. Response to therapy was recorded and collected on a weekly basis using the Gastrointestinal Symptom Rating Scale (GSRS).

RESULTS:

Lactobacillus GG was not superior to placebo in relieving abdominal pain (40.0% response rate in the placebo group vs 44.0% in the Lactobacillus GG group; P=.774). There was no difference in the other gastrointestinal symptoms, except for a lower incidence of perceived abdominal distention (P=.02 favoring Lactobacillus GG).

CONCLUSIONS:

Lactobacillus GG was not superior to placebo in the treatment of abdominal pain in children with IBS but may help relieve such symptoms as perceived abdominal distention.

PMID:
16126049
DOI:
10.1016/j.jpeds.2005.05.015
[Indexed for MEDLINE]

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