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Gene. 1992 Jun 15;115(1-2):93-6.

Sequence similarity between macrolide-resistance determinants and ATP-binding transport proteins.

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Lilly Research Laboratories, Division of Eli Lilly and Company, Indianapolis, IN 46285.


The three macrolide-resistance-encoding genes, tlrC from Streptomyces fradiae, srmB from Streptomyces ambofaciens, and carA from Streptomyces thermotolerans, encode proteins that possess significant sequence similarity to ATP-dependent transport proteins. The N-terminal and C-terminal halves of these proteins are very similar to each other and contain highly conserved regions that resemble ATP-binding domains typically present within the superfamily of ATP-dependent transport proteins. These observations suggest that the mechanism by which these genes confer resistance to macrolides is due to export of the antibiotics, a process that is driven by energy derived from ATP hydrolysis.

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