Format

Send to

Choose Destination
Chemistry. 2006 Mar 20;12(10):2658-62.

SAR by ILOEs: an NMR-based approach to reverse chemical genetics.

Author information

1
The Burnham Institute, 10901 North Torrey Pines Rd. La Jolla, CA 92037, USA.

Abstract

Reverse chemical genetics is an emerging technique that makes use of small molecule inhibitors to characterize how a protein functions. In this regard, we have developed an NMR-based approach (SAR by ILOEs) that enables the identification of high affinity ligands for a given protein target without the need of a specific assay. Our approach is of general applicability and could result very powerful in reverse chemical-genetics studies, target validation, and lead discovery. We report a recent application on the design and synthesis of compounds that inhibit protein-membrane interactions.

PMID:
16121405
DOI:
10.1002/chem.200500636
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center