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Photochem Photobiol Sci. 2005 Sep;4(9):699-708. Epub 2005 Mar 21.

Ultraviolet B radiation-induced immunosuppression: molecular mechanisms and cellular alterations.

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1
Institut für Umweltmedizinische Forschung (IUF), (Institute for Environmental Medical Research at the Heinrich-Heine University Duesseldorf gGmbH), Auf'm Hennekamp 50, 40225 Düsseldorf, Germany.

Abstract

About 30 years ago, the discovery of the connection between UV radiation and the immune system triggered the field of photoimmunology. In that time, many aspects were studied, and a complex picture emerged. UV absorption results in multi-tiered molecular and cellular UV radiation-induced events, eventually affecting the immune system. The shorter wavelengths of the UV spectrum, i.e. UVB appear to be the most critical players for impairing immune reactions. This review summarizes and discusses UVB radiation-induced effects on the skin, considering the primary efferent molecular events following energy absorption of UVB radiation, ending with the various afferent cellular changes, such as induction of regulatory T cells.

PMID:
16121280
DOI:
10.1039/b418378a
[Indexed for MEDLINE]
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