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AJR Am J Roentgenol. 2005 Sep;185(3):763-7.

The role of blood-brain barrier permeability in brain tumor imaging and therapeutics.

Author information

1
Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA.

Abstract

OBJECTIVE:

Our purpose is to describe methods of assessing leakiness of the blood-brain barrier and explain mechanisms for exploiting the blood-brain barrier for therapeutic purposes.

CONCLUSION:

Knowledge of the workings of the blood-brain barrier is important for an understanding of the ways in which blood-brain barrier permeability may be used as a surrogate marker for drug therapeutic response. Manipulation of the blood-brain barrier may provide a means for selectively targeting tumors for drug delivery.

PMID:
16120931
DOI:
10.2214/ajr.185.3.01850763
[Indexed for MEDLINE]

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