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Mitochondrion. 2001 Oct;1(3):237-48.

Antibody-based approaches to diagnosis and characterization of oxidative phosphorylation diseases.

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Institute of Molecular Biology, University of Oregon, Eugene, OR 97403 1229, USA.


Mitochondrial disorders caused by defects in oxidative phosphorylation function are difficult to diagnose. Here we review the emerging use of antibody-based approaches for this diagnosis. Novel methods involving immunohistochemistry and immunocapture of defective enzymes for characterization are described that add to the arsenal of approaches available.

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