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Org Lett. 2005 Sep 1;7(18):4045-8.

Enantioselective analysis of an asymmetric reaction using a chiral fluorosensor.

Author information

1
Department of Chemistry, Georgetown University, Washington, D.C. 20057, USA.

Abstract

An axially chiral 1,8-dipyridylnaphthalene N,N'-dioxide has been employed in enantioselective fluorescence analysis of the enzymatic kinetic resolution of trans-1,2-diaminocyclohexane. The procedure eliminates cumbersome purification and derivatization steps required by traditional methods. The results demonstrate the potential of fluorescence spectroscopy using suitable chiral chemosensors for real-time analysis of the enantiomeric composition of chiral compounds and for high-throughput screening of asymmetric reactions. [structure: see text].

PMID:
16119963
DOI:
10.1021/ol0516216

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