Hyperthyroidism and cerebral venous thrombosis

Eur Neurol. 2005;54(2):78-80. doi: 10.1159/000087717. Epub 2005 Aug 23.

Abstract

The demonstration of an underlying prothrombotic condition in cerebral venous thrombosis (CVT) may have important practical consequences in terms of prevention. Thyrotoxicosis through a hypercoagulable state may be a predisposing factor for CVT. The authors present the cases of 4 patients who developed CVT and hyperthyroidism. At the acute stage, hyperthyroidism was associated with an increase in factor VIII (FVIII). At follow-up, FVIII level remained increased in 2 patients. Hyperthyroidism may have an impact on FVIII level. Accordingly in patients with hyperthyroidism and neurological symptoms, the diagnosis of CVT should be considered and an exhaustive coagulation screening may be appropriate.

Publication types

  • Case Reports

MeSH terms

  • Factor VIII / analysis*
  • Female
  • Humans
  • Hyperthyroidism / blood*
  • Hyperthyroidism / complications
  • Intracranial Thrombosis / blood
  • Intracranial Thrombosis / diagnosis
  • Intracranial Thrombosis / etiology*
  • Middle Aged

Substances

  • Factor VIII