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Br J Sports Med. 2005 Sep;39(9):604-10.

IGFBP-3, a sensitive marker of physical training and overtraining.

Author information

1
Laboratoire de Physiologie de la Performance Motrice, Université Blaise Pascal, Bat Biologie B, Les Cézeaux, 63177 Aubière Cedex, France.

Abstract

OBJECTIVE:

To investigate the response of the somatotrope axis (insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3)) to intense exercise in relation to tiredness.

METHODS:

The study involved 11 rugby players who completed a questionnaire intended to evaluate fitness or, conversely, overtraining and who agreed to plasma samples being taken before and after an international rugby match.

RESULTS:

The main finding of our study is that we observed strong negative correlations between IGF-1 (r = 0.652) and IGFBP-3 (r = 0.824) levels and the overtraining state estimated using the French Society of Sport Medicine questionnaire. In particular, there was a fall (of up to 25%) in IGFBP-3 levels after the match in the more fatigued subjects compared to an increase (of up to 40%) in fit subjects.

CONCLUSIONS:

A fall in IGFBP-3 in response to an intense bout of exercise may represent an index of tiredness in highly trained sportsmen, as indicated by the scores obtained from the overtraining questionnaire.

PMID:
16118296
PMCID:
PMC1725308
DOI:
10.1136/bjsm.2004.014183
[Indexed for MEDLINE]
Free PMC Article

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