Send to

Choose Destination
See comment in PubMed Commons below
J Am Chem Soc. 2005 Aug 31;127(34):11906-7.

Single-walled carbon nanotube biosensors using aptamers as molecular recognition elements.

Author information

  • 1Advanced Materials Division, Korea Research Institute of Chemical Technology, Daejeon 305-343, Korea.


We report the real-time detection of protein using SWNT-FET-based biosensors comprising DNA aptamers as molecular recognition elements. Anti-thrombin aptamers that are highly specific to serine protein thrombin were immobilized on the sidewall of a SWNT-FET using CDI-Tween linking molecules. The binding of thrombin aptamers to SWNT-FETs causes a rightward shift of the threshold gate voltages, presumably due to the negatively charged backbone of the DNA aptamers. While the addition of thrombin solution causes an abrupt decrease in the conductance of the thrombin aptamer immobilized SWNT-FET, no noticeable change was observed with elastase.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Support Center