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Curr Genet. 1992 Jul;22(1):9-11.

6-Azauracil inhibition of GTP biosynthesis in Saccharomyces cerevisiae.

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IBMC du CNRS, UPR SMBMR 9002, Strasbourg, France.


The addition of 6-azauracil to the growth medium causes a strong reduction of the GTP level in the nucleotide pool of Saccharomyces cerevisiae. In-vitro experiments show a strong inhibition of IMP dehydrogenase activity by 6-azaUMP explaining the preceding effect. PPR2 mutants, previously characterized by an increased sensitivity to 6-azauracil compared to the wild-type, are specifically susceptible to the lowering of the GTP pool, and are able to grow in presence of 6-azauracil when guanine is added to the medium.

[Indexed for MEDLINE]

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