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Nat Immunol. 2005 Sep;6(9):889-94. Epub 2005 Aug 14.

Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues.

Author information

1
Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, California 94305, USA. debes@stanford.edu

Abstract

Lymphocytes travel throughout the body to carry out immune surveillance and participate in inflammatory reactions. Their path takes them from blood through tissues into lymph and back to blood. Molecules that control lymphocyte recruitment into extralymphoid tissues are well characterized, but exit is assumed to be random. Here, we showed that lymphocyte emigration from the skin was regulated and was sensitive to pertussis toxin. CD4(+) lymphocytes emigrated more efficiently than CD8(+) or B lymphocytes. T lymphocytes in the afferent lymph expressed functional chemokine receptor CCR7, and CCR7 was required for T lymphocyte exit from the skin. The regulated expression of CCR7 by tissue T lymphocytes may control their exit, acting with recruitment mechanisms to regulate lymphocyte transit and accumulation during immune surveillance and inflammation.

Comment in

PMID:
16116468
PMCID:
PMC2144916
DOI:
10.1038/ni1238
[Indexed for MEDLINE]
Free PMC Article

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