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Nat Neurosci. 2005 Sep;8(9):1139-41. Epub 2005 Aug 7.

Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus.

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1
Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, 8. Szigony u. 43., Budapest, H-1083 Hungary.

Erratum in

  • Nat Neurosci. 2007 Jan;10(1):134.

Abstract

The functions of 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid found in the brain, remain largely unknown. Here we show that two previously unknown inhibitors of monoacylglycerol lipase, a presynaptic enzyme that hydrolyzes 2-AG, increase 2-AG levels and enhance retrograde signaling from pyramidal neurons to GABAergic terminals in the hippocampus. These results establish a role for 2-AG in synaptic plasticity and point to monoacylglycerol lipase as a possible drug target.

PMID:
16116451
DOI:
10.1038/nn1521
[Indexed for MEDLINE]
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