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Neurology. 2005 Aug 23;65(4):642-4.

Nocturnal sleep apnea/hypopnea is associated with lower memory performance in APOE epsilon4 carriers.

Author information

1
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305-5550, USA. roh@leland.stanford.edu

Abstract

The authors investigated the relationship between obstructive sleep apnea/hypopnea (OSAH) and cognition in 36 older adults, 18 APOE epsilon4 carriers, and 18 non-carriers. Greater numbers of respiratory events negatively impacted memory function in epsilon4 carriers only. This is the first study to provide preliminary evidence for a negative interaction of APOE epsilon4 and OSAH on memory in older adults, which may have important implications for treating cognitive decline and delaying dementia onset.

[Indexed for MEDLINE]

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