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Bioorg Med Chem Lett. 2005 Nov 1;15(21):4770-3.

New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors.

Author information

1
Pfizer Global Research and Development, Groton, CT 06340, USA. bernard.hulin@pfizer.com

Abstract

Cyclohexylglycine amides of various fluorinated pyrrolidines and azetidines were prepared and tested for activity against dipeptidyl peptidase IV and in vivo in the KK mouse model of type 2 diabetes. The tetrafluoropyrrolidide, cis-3,4-difluoropyrrolidide and the fluorinated azetidides displayed unexpectedly strong activity.

PMID:
16115768
DOI:
10.1016/j.bmcl.2005.07.026
[Indexed for MEDLINE]

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