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Bioorg Med Chem Lett. 2005 Oct 15;15(20):4589-93.

Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists.

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratories, MRLSDB2 3535 General Atomics Court, San Diego, CA 92121, USA. pchua@cylenepharma.com

Abstract

Structure-activity relationship studies leading to the discovery of novel mGlu5 receptor antagonists are described. These compounds show high in vitro potency, have good in vivo receptor occupancy, and a reasonable intravenous pharmacokinetic profile.

PMID:
16115767
DOI:
10.1016/j.bmcl.2005.06.099
[Indexed for MEDLINE]

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