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Eur Urol. 2005 Sep;48(3):438-44. Epub 2005 Mar 29.

Upper urinary tract cancer: location is correlated with prognosis.

Author information

1
Department Urology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam. h_vanderpoel@nki.nl

Abstract

OBJECTIVES:

Evaluate prognostic information of anatomical location in patients with upper tract transitional cell carcinoma (UTTCC).

METHODS:

Retrospective analysis of 149 upper tract transitional cell carcinoma (UTTCC) patients from a single institute treated surgically between 1988 and 2003.

RESULTS:

Transmural tumor growth (pT3 or pT4) was less common in distally located tumors (33%) compared to mid (44%), proximal ureter (75%) or pyelum tumors (41%). Tumor stage was the best predictor of disease specific survival. Distally located tumors had a significantly better survival than proximally located cancers (median survival 53 months versus 16 months for tumors in the proximal ureter). Bladder cancer was found in 73 (49%) patients. Invasive UTTCC were less likely to be associated bladder cancer (RR 0.66, 95%CI 0.43-0.98). In a multivariate analysis both tumor stage and location in the upper tract were predictive of disease specific survival after UTTCC diagnosis.

CONCLUSION:

Tumor location in the proximal upper tract predicts stage-independent poor prognosis in patients with UTTCC.

PMID:
16115524
DOI:
10.1016/j.eururo.2005.03.009
[Indexed for MEDLINE]
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