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Biochem Biophys Res Commun. 2005 Sep 30;335(3):734-8.

Insulin-cell penetrating peptide hybrids with improved intestinal absorption efficiency.

Author information

1
Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ 07030, USA. jliang2@stevens.edu

Abstract

Cell-penetrating peptide (CPP) was linked to insulin to form insulin-CPP hybrids. The intestinal absorption efficiency of CPP hybridized insulin was 6-8 times increased compared to normal insulin as tested on Caco-2 cell monolayer, a widely used in vitro model for intestinal absorption. Insulin-CPP hybrid transportation seemed to be through an active and transcytosis-like mechanism. Importantly, insulin in hybrids kept intact after they passed through the Caco-2 cell monolayer. This study provides a new clue for oral insulin development.

PMID:
16115469
DOI:
10.1016/j.bbrc.2005.07.142
[Indexed for MEDLINE]

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