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Thromb Haemost. 2005 Jul;94(1):4-16.

Glycosaminoglycan: a candidate to stimulate the repair of chronic wounds.

Author information

1
Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, P.O. Box 913, Dunedin, New Zealand. phil.peplow@stonebow.otago.ac.nz

Abstract

A persistent inflammation with large numbers of neutrophils is found in chronic wounds. Secretory products released from the neutrophils, which include proteinases and a heparin-binding protein, are detrimental to wound healing as they cause degradation of the extracellular matrix and growth factors, and promote further recruitment of neutrophils to the wound area. The neutrophil-derived elastase, cathepsin G, proteinase-3 and heparin-binding protein are cationic, and it is hypothesized that their effects can be inhibited by electrostatic binding with certain anionic polymers such as glycosaminoglycans or functionalized dextrans. A sustained delivery of such compounds alone or in combination from a biodegradable carrier may provide a stimulus for these wounds to pass to the next stage of repair.

PMID:
16113778
DOI:
10.1160/TH04-12-0812
[Indexed for MEDLINE]

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