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Nat Cell Biol. 2005 Sep;7(9):870-9. Epub 2005 Aug 21.

PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival.

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1
Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.

Abstract

The microvasculature consists of endothelial cells and their surrounding pericytes. Few studies on the regulatory mechanisms of tumour angiogenesis have focused on pericytes. Here we report the identification of tumour-derived PDGFRbeta (+) (platelet-derived growth factor receptor beta) progenitor perivascular cells (PPCs) that have the ability to differentiate into pericytes and regulate vessel stability and vascular survival in tumours. A subset of PDGFRbeta (+) PPCs is recruited from bone marrow to perivascular sites in tumours. Specific inhibition of PDGFRbeta signalling eliminates PDGFRbeta (+) PPCs and mature pericytes around tumour vessels, leading to vascular hyperdilation and endothelial cell apoptosis in pancreatic islet tumours of transgenic Rip1Tag2 mice.

PMID:
16113679
PMCID:
PMC2771163
DOI:
10.1038/ncb1288
[Indexed for MEDLINE]
Free PMC Article

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