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Neuroimage. 2006 Jan 15;29(2):662-6. Epub 2005 Aug 19.

Striatal D2 receptor binding as a marker of prognosis and outcome in untreated first-episode psychosis.

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Department of Psychiatry, Hospital de la Sta Creu I Sant PauC, Universidad Autónoma de Barcelona (UAB) [corrected] Sant Antoni Maria Claret, 16708025 Barcelona, Spain.

Erratum in

  • Neuroimage. 2006 Sep;32(3):1483.


In a preliminary 123I-IBZM SPECT study in first-episode psychosis, a relationship between striatal dopaminergic D2 receptor (D2R) binding and premorbid adjustment was suggested. These results were replicated in the present study (n = 18), and D2R binding at diagnosis predicted a high probability for schizophrenia outcome by 2-year follow-up. The present findings contribute to the evidence of abnormal D2R binding in schizophrenia and suggest that SPECT might be useful for outcome prediction in first-episode psychosis.

[Indexed for MEDLINE]

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