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Bioorg Med Chem. 2005 Dec 1;13(23):6374-80. Epub 2005 Aug 19.

Synthesis and biological evaluation of polyhydroxycurcuminoids.

Author information

1
Laila Impex Research Centre, Unit 1, Phase III, Jawahar Autonagar, Vijayawada, India.

Abstract

A series of curcumin analogs (1-3, 5a-5t) was synthesized through the condensation of appropriately protected hydroxybenzaldehydes with acetylacetone, followed by deprotection. The antioxidant activity of these analogs was determined by superoxide free radical nitroblue tetrazolium and DPPH free radical scavenging methods and the polyhydroxycurcuminoids (5l-5s) displayed excellent antioxidant activity. These analogs showed cytotoxicity to lymphocytes and promising tumor-reducing activity on Dalton's lymphoma ascites tumor cells.

PMID:
16112582
DOI:
10.1016/j.bmc.2005.06.050
[Indexed for MEDLINE]

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