Format

Send to

Choose Destination
Eur J Pharmacol. 2005 Sep 5;519(1-2):191-3.

Proadrenomedullin N-terminal peptide and cortistatin activation of MrgX2 receptor is based on a common structural motif.

Author information

1
Department of Pharmacology, 354 MedSurge II University of California, Irvine, Irvine CA 92697-4625, USA. hnothack@uci.edu

Abstract

The G protein-coupled receptor MrgX2 belongs to the large family of the Mas-related genes or sensory neuron-specific G protein-coupled receptors. The MrgX2 receptor has been shown to be activated by the peptides cortistatin and proadrenomedullin N-terminal peptides (PAMP). Here we investigated the structure activity relationship of PAMP and identified key structural features that are shared with cortistatin and might explain why two apparently unrelated peptides are able to activate a single G protein-coupled receptor.

PMID:
16111673
DOI:
10.1016/j.ejphar.2005.07.001
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center