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Pediatr Blood Cancer. 2005 Oct 15;45(5):644-8.

Etoposide, vincristine, and cyclosporin A with standard-dose radiation therapy in newly diagnosed diffuse intrinsic brainstem gliomas: a pediatric oncology group phase I study.

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1
Hospital for Sick Children, Toronto, Ontario, Canada. mark.greenberg@sickkids.ca

Abstract

BACKGROUND:

Brainstem gliomas (BSGs) are resistant to all therapy. Based on their imaging characteristics, we postulated that inhibition of P-glycoprotein (P-gp) associated with endothelial cells of the blood-brain barrier might enhance penetration of xenobiotic antineoplastics.

PROCEDURE:

Seven patients were enrolled in a Phase I study of etoposide, continuous infusion cyclosporine A given with and escalating doses of vincristine and concomitant standard-dose irradiation.

RESULTS:

Six patients were entered at the first level and one at the second. Closure of the study was mandated by dose-limiting neurotoxicity, consisting of seizures associated with white-matter changes, and alteration of consciousness with bulbar signs. One patient had tumor necrosis at 6 weeks, suggesting some tumor effect. Median survival for the group was 11 months, and for the patients who completed more than 1 month of therapy it was 11 months.

CONCLUSION:

This regimen proved excessively toxic.

PMID:
16110498
DOI:
10.1002/pbc.20382
[Indexed for MEDLINE]
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