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Neuroreport. 1992 Jan;3(1):109-12.

Cloning of drebrin A and induction of neurite-like processes in drebrin-transfected cells.

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Laboratory of Neurochemistry, National Institute for Physiological Sciences, Okazaki, Japan.

Erratum in

  • Neuroreport 1992 Mar;3(3):following 285.


The developmentally-regulated neuron-specific protein, drebrin A, is expressed first at the time of outgrowth and maturation of dendrites, and is localized within dendrites of the adult brain. A cDNA clone of adult rat drebrin A was isolated and sequenced. There is no overall homology with other reported protein sequences except chicken drebrins. We constructed the expression vector MIW-DA containing the drebrin A cDNA. Transfection of nonneuronal cells with MIW-DA induced the formation of highly branched neurite-like cell processes. In these process-bearing transfectants, expressed debrin A is concentrated in submembraneous regions of the cell. Furthermore, actin concentration is higher in these cells than other fibroblasts. These results suggest a possible role of drebrin A in neurite outgrowth.

[Indexed for MEDLINE]

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