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Scand J Gastroenterol. 2005 Jul;40(7):822-6.

Lactose intolerance: lactose tolerance test versus genotyping.

Author information

1
Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Sweden. peter.ridefelt@medsci.uu.se

Abstract

OBJECTIVE:

Adult lactose intolerance, which affects the majority of the population in the world, has been associated with a single nucleotide polymorphism, C-13910T, located upstream of the lactase gene.

MATERIAL AND METHODS:

Adult patients undergoing lactose tolerance tests with lactose challenge and plasma glucose measurements were included in the study comprising 44 Swedes and 7 non-Swedish individuals. A real-time PCR method was established for the genotyping.

RESULTS:

Out of 51 patients 48 had concordant results on genotyping and lactose tolerance tests, e.g. -13910T/T and -13910C/T genotypes had high glucose elevations. All patients with the heterozygous genotype, -13910C/T, had high glucose elevations, and no gene-dose relationship was observed when comparing maximal glucose increases for cases with -13910C/T and -13910T/T genotypes.

CONCLUSIONS:

Genotyping could replace lactose challenge as a first-stage screening test in adults of European descent, but should be used together with tolerance tests in children and patients where secondary lactose intolerance is suspected.

PMID:
16109658
DOI:
10.1080/00365520510015764
[Indexed for MEDLINE]
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