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Trends Parasitol. 2005 Oct;21(10):456-61.

The Plasmodium sporozoite survives RTS,S vaccination.

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1
Equipe Parasitologie Comparée et Modèles Expérimentaux, USM0307, CNRS IFR101, Muséum National d'Histoire Naturelle, CP52, 61 Rue Buffon, 75231 Paris Cedex 05, France. snounou@mnhn.fr

Abstract

The outcome of the Phase IIb trial of RTS,S (a vaccine comprising the polypeptides RTS and S) in young Mozambican children consolidated hopes that effective vaccination against malaria is a step nearer, and even elicited a generous promise of commitment from the Chancellor of the Exchequer of the UK. However, it seems that both optimism and generosity should be moderated by the failure of this vaccine to induce meaningful protection against infection by Plasmodium falciparum and that we should await confirmation of its efficacy in diminishing the incidence of severe malaria.

PMID:
16109504
DOI:
10.1016/j.pt.2005.08.002
[Indexed for MEDLINE]
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