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Homocysteine and folate metabolism in depression.

Author information

1
Baylor University Medical Center, Institute of Metabolic Disease, Dallas, TX 75226, USA. teodorob@baylorhealth.edu

Abstract

Homocysteine is a sensitive marker of folate and vitamin B12 deficiency. Numerous studies have confirmed the association between folate deficiency and depression. It is not completely understood whether homocysteine is solely a marker for folate deficiency or if it may play a more direct role in the expression of mood disorders. This review describes the biochemical, neurochemical and clinical correlations of folate deficiency and hyperhomocysteinemia in relation to depression.

PMID:
16109454
DOI:
10.1016/j.pnpbp.2005.06.021
[Indexed for MEDLINE]

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