Format

Send to

Choose Destination
Lancet Neurol. 2005 Sep;4(9):543-55.

Neurological complications of HIV infection.

Author information

1
HIV Neurosciences Program, Johns Hopkins University, Baltimore, MD, USA. jm@jhmi.edu

Abstract

Cognitive disorders, vacuolar myelopathy, and sensory neuropathies associated with HIV are the most common disorders in patients with HIV AIDS, and are the focus of this review. These disorders are treatable and of those associated with HIV AIDS the pathogenic mechanisms are the most understood. Although triggered by productive HIV macrophage infections, aberrant immune activation plays a major role in inducing the CNS disorders. Novel therapies aimed at these inflammatory mechanisms can be effective. The sensory neuropathies associated with HIV infection are a major cause of morbidity; incidence may be increased by the toxic effects of specific antiretroviral drugs within the peripheral nervous system.

PMID:
16109361
DOI:
10.1016/S1474-4422(05)70165-4
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center