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Immunology. 2005 Sep;116(1):1-12.

Chemokine control of lymphocyte trafficking: a general overview.

Author information

1
Theodor Kocher Institute, University of Bern, Freiestr. 1, 3012 Bern, Switzerland. jstein@tki.unibe.ch

Abstract

Chemokines are a large family of small, generally secreted polypeptides which guide lymphocyte movement throughout the body by controlling integrin avidity and inducing migration. Here, we look at recent, exciting findings on chemokine function throughout lymphocyte development and co-ordinated T and B cell migration during immune responses. Finally, we will review data on the regional control of immunity by tissue-specific chemokine receptors on effector/memory lymphocytes.

PMID:
16108812
PMCID:
PMC1802414
DOI:
10.1111/j.1365-2567.2005.02183.x
[Indexed for MEDLINE]
Free PMC Article

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