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Genesis. 2005 Oct;43(2):80-6.

Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene.

Author information

1
Department of Biochemistry and Molecular Biology, and the Howard Hughes Medical Institute, The University of Chicago, Chicago , Illinois, USA. sooyoung@uchicago.edu

Abstract

We generated transgenic mice expressing firefly (Photinus pyralis) luciferase (luc) under the control of the mouse insulin I promoter (MIP). The mice have normal glucose tolerance and pancreatic islet architecture. The luciferase-expressing beta cells can be readily visualized in living mice using whole-body bioluminescent imaging. The MIP-luc transgenic mice may be useful for monitoring changes in beta cell function or mass in living animals with normal or altered metabolic states.

PMID:
16108006
DOI:
10.1002/gene.20157
[Indexed for MEDLINE]

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