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J Infect Dis. 2005 Sep 15;192(6):1047-51. Epub 2005 Aug 10.

A soluble receptor decoy protects rats against anthrax lethal toxin challenge.

Author information

1
Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California, USA.

Abstract

Successful postexposure treatment for inhalation anthrax is thought to include neutralization of anthrax toxin. The soluble anthrax toxin receptor/tumor endothelial marker 8 and capillary morphogenesis protein 2 (sATR/TEM8 and sCMG2, respectively) receptor decoys bind to anthrax toxin protective antigen (PA) and compete with cellular receptors for binding. Here, we show that, in a tissue-culture model of intoxication, sCMG2 is a 11.4-fold more potent antitoxin than sATR/TEM8 and that this increased activity corresponds to an approximately 1000-fold higher PA-binding affinity. Stoichiometric concentrations of sCMG2 protect rats against lethal toxin challenge, making sCMG2 one of the most effective anthrax antitoxins described to date.

PMID:
16107958
DOI:
10.1086/432731
[Indexed for MEDLINE]

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