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Nature. 2005 Aug 18;436(7053):973-8.

Hepatitis C and liver transplantation.

Author information

1
Department of Medicine, and Center for Liver Disease and Transplantation, Columbia University College of Physicians and Surgeons, 622 West 168th Street, New York, New York 10032, USA. rb464@columbia.edu

Abstract

Liver transplantation is a life-saving therapy to correct liver failure, portal hypertension and hepatocellular carcinoma arising from hepatitis C infection. But despite the successful use of living donors and improvements in immunosuppression and antiviral therapy, organ demand continues to outstrip supply and recurrent hepatitis C with accelerated progression to cirrhosis of the graft is a frequent cause of graft loss and the need for retransplantation. Appropriate selection of candidates and timing of transplantation, coupled with better pre- and post-transplant antiviral therapy, are needed to improve outcomes.

PMID:
16107838
DOI:
10.1038/nature04083
[Indexed for MEDLINE]

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