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Nature. 2005 Aug 18;436(7053):953-60.

Challenges and successes in developing new therapies for hepatitis C.

Author information

1
Istituto di Ricerche di Biologia Molecolare P. Angeletti, Via Pontina km 30.600, 00040 Pomezia-Rome, Italy. raffaele_defrancesco@merck.com

Abstract

Hepatitis C virus (HCV) will continue to be a serious global health threat for many years to come because of the chronic nature of the infection, its high prevalence and the significant morbidity of the resulting disease. Recently, a small number of molecules have produced encouraging results in proof-of-concept clinical trials. At the same time, preclinical evidence is accumulating that development of resistance will eventually limit the efficacy of new drugs. Thus, combinations of multiple agents will be required to treat chronic HCV infection.

PMID:
16107835
DOI:
10.1038/nature04080
[Indexed for MEDLINE]

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