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Nature. 2005 Aug 18;436(7053):930-2.

Unscrambling hepatitis C virus-host interactions.

Author information

1
The Scripps Research Institute, La Jolla, California 92037, USA. fchisari@scripps.edu

Abstract

The human suffering exacted by the hepatitis C virus is enormous. Hundreds of thousands of people die each year from liver failure and cancer caused by this infection. There is no vaccine, and the available antiviral drugs are toxic, expensive and only partly effective. Progress has been hindered by the absence of cell culture and small-animal models of the infection. Nonetheless, recent advances have yielded several promising new antiviral drugs and enhanced the prospects of developing a vaccine. The recent development of a robust in vitro hepatitis C virus infection system will aid this search.

PMID:
16107831
DOI:
10.1038/nature04076
[Indexed for MEDLINE]

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