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Curr Opin Cell Biol. 2005 Oct;17(5):499-508.

Cadherins and catenins in breast cancer.

Author information

1
Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA. cowinp01@med.nyu.edu

Abstract

Recent studies show that cadherins and catenins are hormonally regulated and carry out physiological roles during mammary development but have pathological effects when deregulated. E-cadherin expression is irreversibly lost in invasive lobular breast cancer (ILC). Animal models of ILC provide mechanistic insight, confirming that E-cadherin serves as both a tumor suppressor and an invasion suppressor in ILC. Ductal breast cancer involves complex, reversible, epigenetic modulation of multiple cadherins. Transcriptional regulators of E-cadherin have been identified that induce epithelial-to-mesenchymal transitions. Catenins are lost or mislocalized in tumors lacking cadherins. However, beta-catenin signaling is upregulated by numerous pathways in >50% of breast tumors and animal models suggest its oncogenic function in breast relates to its role in mammary progenitor cell expansion.

PMID:
16107313
DOI:
10.1016/j.ceb.2005.08.014
[Indexed for MEDLINE]

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