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FEBS Lett. 2005 Oct 31;579(26):5841-9. Epub 2005 Aug 9.

Structural domains in RNAi.

Author information

1
Department of Biochemistry, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA.

Abstract

Structural and biochemical studies have begun to elucidate the pathway of RNA silencing that leads to the formation of the RISC complex. The outstanding feature of this pathway is the precise recognition and processing of double-stranded RNA. We present a review of recent structures that illustrate the molecular mechanisms contributing to these two related functions, highlighting models of Drosha, Dicer, and RISC function.

PMID:
16107250
PMCID:
PMC2702771
DOI:
10.1016/j.febslet.2005.07.072
[Indexed for MEDLINE]
Free PMC Article

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