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Nat Rev Mol Cell Biol. 2005 Sep;6(9):738-42. doi: 10.1038/nrm1710.

Peroxisomal matrix protein import: the transient pore model.

Author information

1
Institute for Physiological Chemistry, Faculty of Medicine, Ruhr-University Bochum, Germany. ralf.erdmann@rub.de

Abstract

Peroxisomes import folded, even oligomeric, proteins, which distinguishes the peroxisomal translocation machinery from the well-characterized translocons of other organelles. How proteins are transported across the peroxisomal membrane is unclear. Here, we propose a mechanistic model that conceptually divides the import process into three consecutive steps: the formation of a translocation pore by the import receptor, the ubiquitylation of the import receptors, and pore disassembly/ receptor recycling.

PMID:
16103872
DOI:
10.1038/nrm1710
[Indexed for MEDLINE]

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