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Cytogenet Genome Res. 2005;111(2):101-6.

Chromosomics.

Author information

1
Institute of Human Genetics and Anthropology, Jena, Germany. ucla@mti.uni-jena.de

Abstract

The term "chromosomics" is introduced to draw attention to the three-dimensional morphological changes in chromosomes that are essential elements in gene regulation. Chromosomics deals with the plasticity of chromosomes in relation to the three-dimensional positions of genes, which affect cell function in a developmental and tissue-specific manner during the cell cycle. It also deals with species-specific differences in the architecture of chromosomes, which has been overlooked in the past. Chromosomics includes research into chromatin-modification-mediated changes in the architecture of chromosomes, which may influence the functions and life-spans of cells, tissues, organs and individuals. It also addresses the occurrence and prevalence of chromosomal gaps and breaks.

PMID:
16103649
DOI:
10.1159/000086377
[Indexed for MEDLINE]

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